Watford's Senegalese winger Ismaila Sarr was injured on international duty in an African Cup of Nations qualifier against Congo on Wednesday night.
The Hornets' record signing started in the 2-0 win, but was taken off shortly after half-time with a problem believed to be with his right ankle.
After a hamstring injury had kept the 21-year-old out of action for a number of weeks, he looked set to be available for the next game against Burnley.
This latest setback could put that return in doubt, though it remains to be seen how serious the problem is.
Sarr's namesake Sidy opened the scoring for Senegal before Habib Diallo doubled the lead.
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