The interchange between the A41 and the M1, at junction 5 near Watford, is set to close overnight from tomorrow.
The roundabout at the Berrygrove Interchange is due to be closed overnight from 10pm until 5am from tomorrow (Sunday, March 3) until Thursday, March 21.
Resurfacing works has caused the closure, with disruption and traffic likely.
Emergency access will be maintained at the site, with diversion routes also in place.
The A4008 Stephenson Way will be closed for the duration of the works - between 10pm and 5am - up to the roundabout with Colonial Way.
Elsewhere, the M1 will be closed between 10pm and 5am from Wednesday (March 6) until next Saturday (March 9) in both directions, between junctions 6 and 8.
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